Scientist I/II, In Vivo Pharmacology
Ikena Oncology (NASDAQ: IKNA) is a clinical-stage, targeted oncology company that discovers and develops biomarker-driven therapies for cancer patients who need life-saving treatment, by understanding what drives their disease. Ikena is advancing five clinical, preclinical, and discovery programs and has a global strategic collaboration with Bristol Myers Squibb. Since inception, Ikena has raised over $300 million from leading life sciences investors and companies that include Atlas Venture, OrbiMed, BMS, Fidelity, Omega Funds, Surveyor Capital (a Citadel company), Invus, Farallon Capital Management, BVF Partners, Cowen Healthcare Investments, Logos Capital, and HealthCor Management. Ikena priced its IPO in March 2021 and trades on the NASDAQ (Ticker: IKNA).
We are seeking an experienced in vivo oncology scientist I/II to contribute to progressing our research projects. This position is within our Cancer Biology team, a group whose mission is to discover, evaluate, and develop novel therapeutics. The successful candidate will bring a sense of urgency and commitment to support our research programs and deliver novel patient-directed therapies to patients.
- Work closely with project teams to identify and develop mouse tumor models that align with program targets of interest
- Independently design and conduct in vivo efficacy, PK/PD, and tolerability studies in mouse models to support research projects; perform dosing, blood/tissue collection, and necropsy in adherence to IACUC policies and protocols
- Perform in vitro and ex vivo assays (e.g. qPCR, western blot, cytotoxicity) to define PD/efficacy relationships
- Provide analysis and interpretation of data with clear communication in cross-functional project team meetings, highlighting implications for the broader programs; contribute to high-level decision-making
- Engage with CROs and manage out-sourced in vivo studies
- Maintain accurate, timely, and complete electronic laboratory notebook entries; prepare study protocols, reports, and regulatory documents as needed
- Proactively review literature to bring in the newest scientific findings, ideas, and methods/technologies for research
- Support the organization by maintaining a work environment focused on scientific integrity that fosters learning, open communication, and collaboration
- Serve as a mentor and technical resource for junior scientists
- Additional duties and responsibilities as required
- PhD in Biology, Pharmacology, Biomedical Sciences or related discipline and 2 years of post-doctoral experience, or Master’s degree with at least 8 years of relevant experience in a biotechnology or pharmaceutical company; 4+ years of in vivo experience in industry or academic setting
- Broad knowledge across multiple disciplines including cancer biology and pharmacology; hands-on experience applying pharmacology knowledge and principles of PK, PD, and ADME to support drug development through lead optimization to candidate selection
- Track record of scientific contribution across projects to support project advancement
- Demonstrated experience with in vivo oncology models, including CDX, PDX, and syngeneic mouse models
- Proficiency in animal dosing (SC, PO, and IP routes of administration), tumor monitoring, and necropsy
- Experience with aseptic cell culture technique, and cell and molecular biology assays (including qPCR and western blot) required
- The successful candidate will be a motivated self-starter, with strong communication skills and the ability to work in a fast-paced, team-oriented environment
Personal attributes: team oriented, goal-driven, organized, highly collaborative, open-minded, data-driven, creative, persistent in the face of obstacles and uncertainty, flexible, self-aware of strengths and weaknesses, objective in the evaluation of data and strongly optimistic about overcoming challenges.